The main hazardous chemicals used by Reykjavik Energy (RE) are asbestos, the base material used in insulation foam, chlorine, acids and bases, welding gases, geothermal gases, oil and solvents. In 2023, the use of hazardous chemicals was substantial, as in previous years. Accidents due to the use of hazardous substances are rare and no accidents were reported due to this in the year 2023.

In 2020, an effort was made to decrease the number of hazardous chemicals used, succeeding in lowering their number from 900 down to around 200. Furthermore, improvements were made with regard to their storage, sorting and disposal, and an effort was made to increase employees' awareness by publishing educational material. An example of this is that where hazardous materials are stored for cleaning and in the sewage system, QR codes have been placed on all hazardous materials to facilitate staff access to safety data sheets that describe personal protective equipment and first response actions in case of an accident.